Gender perspective

 Just before menopause, females have actually a reduced threat of metabolic and also cardio conditions compared to males, due to the defensive result of estrogen. Yet defense lowers in perimenopause and also menopause, a duration that's still really improperly researched and also vital for cardiometabolic threat.

Gender perspective

Moreover, in creature versions and also tissue lifestyles our experts have actually discovered really very early alterations—in microglia, in lipid signs including endocannabinoids, and also in neuronal level of sensitivity towards insulin—even just before apparent adjustments show up in peripheral cells. This proposes that the first activate for excessive weight is actually analytical. Incorporating this sex viewpoint is actually important to relocate in the direction of even more exact and also reliable procedures.



Brand-brand new treatments versus excessive weight: incretins and also brain-targeted nanomedicine

Excessive weight procedure has actually transformed drastically considering that 2021 along with the overview of GLP-1 receptor agonists. Semaglutide and also various other incretin medications, originally established for style 2 diabetes mellitus, have actually displayed exceptional weight-loss possible via each peripheral and also core activities. Nonetheless, they have actually recognized constraints : stomach results, reduction of lean mass, significance gain back after discontinuation, or even changeable actions relying on the patient's organic account.


Latest research researches additionally present distinctions through sex: premenopausal females have the tendency to answer much a lot better towards these procedures compared to males.

addressing temporary complications

This presents an obstacle: our experts require treatments that process straight on the human brain, along with better preciseness and also far fewer systemic results. This is actually where brain-targeted nanomedicine opens a brand new horizon. In our team, our experts create nanoplatforms (polymeric micelles, healthy protein nanoparticles or even intranasal solutions) with the ability of uniquely carrying medications towards the human brain. These modern technologies permit our company towards envelop particles that, if carried out without defense, will be actually inadequate or even hazardous, and also towards intended all of them towards the tissues that management cravings and also electricity homeostasis.


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